acute and chronic effect of cigarette on right and left ventricular diastolic function

conclusions chronic smoking caused left ventricular diastolic dysfunction. acute intake caused left and right ventricular diastolic dysfunction. changes persisted up to 30 minutes after smoking, although diastolic blood pressure returned to normal state. objectives the current study aimed to evaluate the acute and chronic effects of smoking on the left and right ventricular (rv) diastolic function. patients and methods one hundred healthy male, 50 smokers and 50 non-smokers, underwent echocardiography, before smoking and 5 and 30 minutes after it to compare diastolic function of left ventricular (lv) and rv and examine the chronic and acute effects of smoking. results atrial late diastolic mitral inflow velocity (am) atrial and late diastolic septal mitral annular velocity (ams) were high in smokers in comparison to those of the control group before smoking, but there was no difference in tricuspid diastolic parameters. five minutes later, isovolumetric relaxation time (ivrt) was prolonged and ams further increased as a sign of lv diastolic dysfunction. similar changes occurred in rv, in favor of acute rv diastolic dysfunction. after 30 minutes, early diastolic tricuspid inflow (et) decreased and ams and late diastolic tricuspid inflow (at) remained high. after five minutes, diastolic blood pressure increased, but returned to normal state after 30 minutes. pulmonary arterial pressure did not change before and after smoking. background one billion people in the world are addicted to cigarettes; due to smoking and related illnesses, over five million people in the world, suffered death yearly. epidemiological studies have shown that more than one case out of 10 cases of cardiovascular deaths, which include 54% of all deaths worldwide, is due to cigarettes.